She may have won an Oscar for her first film role, but Lupita Nyong’o spent the early part of her life hiding her desire to be an actor. Lupita tells Marc about growing up under autocratic rule, living in a country where creative voices were suppressed, and learning how to speak out even when it’s risky. Lupita also explains why she followed up 12 Years a Slave with Star Wars and how A Quiet Place: Day One helped cure her fear of cats. (Check out Lupita’s new podcast Mind Your Own, launching September 19, and her new animated film The Wild Robot, in theaters September 27.)

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It took Chris Robinson a long time to accept being a rock and roll frontman. Even at the height of The Black Crowes’ success, he just thought they were just a group of dudes from Atlanta playing roots music. Now reunited with the band and touring again after releasing their ninth album, Chris tells Marc why it took time and perspective to realize he liked being the guy on lead vocals. Chris also tells Marc about the influence of bands like The Faces and Humble Pie, how he was discouraged from being a singer when he was a kid, and how he healed the rift with his brother and bandmate Rich.

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Drew Lynch never planned on being a comedian. But his pursuit of an acting career got derailed by a traumatic brain injury that left him with a stutter and no career prospects. Drew tells Marc the reason he decided to get on stage and put together a standup act, a decision that made him a finalist on America’s Got Talent and helped him land a recurring guest stint on Marc’s IFC series. Drew also talks about his self-consciousness over his early breaks in comedy and why humility has become a necessary ingredient in his life.

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When the topic of past guests comes up, Marc often mentions Brendon Walsh, a comedian who was on several early WTF episodes as well as Marc’s IFC sitcom. Diving into a full conversation more than a decade since he was last in the garage, Brendon tells Marc about the changes in his life since then, including the break he took from comedy, the tragic death of his podcast co-host, the mistakes he’s come to terms with, and why he currently hosts The World Record podcast with his wife.

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Greg Fitzsimmons returns to WTF after a 13 year absence, but his dynamic with Marc remains the same as it was when they were comics starting out in Boston almost four decades ago. With a new comedy special out, Greg talks with Marc about his unhealthy relationship with worry, how he broke the self-destructive cycles of his family, and how his relationship with Marc evolved from trying to get in a fistfight with him backstage to reminiscing about their road stories and hard-earned victories.

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Over the past four years, Paul W. Downs has been one of the people responsible for constructing the ongoing story of a lifer standup comic on the show Hacks. Paul talks with Marc about how his comedy background is very different from the fictional Deborah Vance, with his training at the UCB Theater, his days at the vanguard of internet video comedy, and his entry into the world of Broad City. They also talk about embarrassment, becoming less odd with age, and the current crisis in comedy development.

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Michael Rooker is known for playing a variety of menacing and intense characters. But menace was something he was always good at, as the protective older brother of six sisters. And intensity is often something people misread because he’s hard of hearing. Michael talks with Marc about growing up in Alabama with no electricity or running water, his bus driver’s outfit helping him land Henry: Portrait of a Serial Killer, his epic Eight Men Out casting story, his embrace of the comic book world by way of Guardians of the Galaxy, and his Horizon reunion with JFK co-star Kevin Costner.

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Blair Socci comes from an athletic family with a hardened ancestral backstory involving throat slashing and exile. But despite her exterior toughness, Blair spent her youth enjoying poetry, journaling and creative writing. If she hadn't caught the comedy bug, she intended to become a novelist. Blair and Marc talk about her volleyball prowess, how athletics prepared her for comedy, and why she recently felt the need to abandon her anti-social media stance.

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When Moon Zappa was on the show back in 2013, she and Marc started dating shortly thereafter. Now that Moon has just written her memoir, Earth to Moon, she and Marc sit down for their first real conversation since their abrupt breakup. Moon talks about the forensic investigation she did of her life, the emotional damage she took from her mother, the pressure of carrying Frank Zappa’s legacy, and the realization that her upbringing was quite sheltered despite her family’s very public image.

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When Marc saw Beth Stelling’s Netflix special, he knew there was something he found familiar. It turns out they both have a similar process of making comedy out of trauma. Beth talks with Marc about the childhood event that informed most of the way she addresses difficult subjects in her act and how speaking up about an abusive relationship led to a backlash that left her reeling. They also talk about life in Ohio and what it was like to film a comedy special in her hometown.

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One of the reasons singer-songwriter Jimmie Dale Gilmore didn’t get a solo record deal until he was in his 40s is because he took an extended time away from music to live in a spiritual community. Jimmie and Marc talk about the search for enlightenment in the midst of being a trendsetter for Americana music. They also talk about Jimmie’s band The Flatlanders, Texas barbecue, hearing loss, Willie Nelson, and Jimmie’s recent collaborations with Dave Alvin from The Blasters.

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