Y Combinator Startup Podcast

Y Combinator

We help founders make something people want.

  • 53 minutes 20 seconds
    The Future Of Brain-Computer Interfaces with Science's Max Hodak

    YC alum Max Hodak is the co-founder of Neuralink and founder of Science, a company building brain-computer interfaces that can restore sight.Science has developed a tiny retinal implant that stimulates cells in the eye to help blind patients see again. More than 40 patients have already received the treatment in clinical trials, including one who recently read a full novel for the first time in over a decade.In this episode of How to Build the Future, Max joined Garry to discuss how BCIs work, what it takes to engineer the brain, and why brain-computer interfaces may become one of the most important technologies of the next decade.

    9 March 2026, 3:34 pm
  • 37 minutes 26 seconds
    How To Avoid AI Design Slop

    As no-code design tools become more common, so do the pitfalls. You know what they look like - the purple gradients, annoying hover effects, sections that fade as you scroll. So how do you avoid a site that feels vibe coded while still taking advantage of these new tools? In this episode of Design Review, YC’s Aaron Epstein is joined by Visiting Partner Raphael Schaad, the founder and designer of Cron (now Notion Calendar). Together they’ll review user submitted sites with an eye for how to leverage these tools and avoid the common vibe coding mistakes.

    6 March 2026, 7:25 pm
  • 19 minutes 45 seconds
    The Fastest Path To Super Intelligence

    Poetiq is a new startup founded by former DeepMind researchers that recently achieved a major jump on the ARC-AGI and Humanity's Last Exam benchmark by layering a recursive self-improvement system on top of existing models. In this episode of Lightcone, Poetiq's Founder & CEO Ian Fischer joined us to discuss how small teams can build “reasoning harnesses” that outperform base models, what that means for startups and why automating prompt engineering may be one of the most powerful levers in AI today.Chapters:00:00 – Intro00:40 – What Is Poetiq?01:07 – Recursive Self-Improvement Explained02:07 – The Fine-Tuning Trap02:59 – “Stilts” for LLMs03:14 – Recursive Self-Improvement vs. Fine-Tuning05:05 – Taking the Top Spot on ARC-AGI06:37 – Beating Claude on Humanity’s Last Exam08:40 – How the Meta-System Works10:26 – Beyond RL: A New S-Curve11:32 – Automating Prompt Engineering13:37 – From 5% to 95% Performance14:50 – Early Access & Putting Your Agent on Stilts16:17 – From YC Founder to DeepMind Researcher18:29 – Advice for Engineers in the AI EraApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs

    27 February 2026, 3:00 pm
  • 23 minutes 21 seconds
    The AI Agent Economy Is Here

    With the takeoff of OpenClaw and MoltBook, a new agent-driven economy is taking shape.


    In this episode of the Lightcone, we took a look at the explosive growth of AI dev tools and whether the time has come for builders to make something agents want.

    21 February 2026, 7:32 pm
  • 50 minutes 10 seconds
    Inside Claude Code With Its Creator Boris Cherny

    A very special guest on this episode of the Lightcone! Boris Cherny, the creator of Claude Code, sits down to share the incredible journey of developing one of the most transformative coding tools of the AI era.

    17 February 2026, 9:59 pm
  • 7 minutes 50 seconds
    The New Way To Build A Startup

    In the AI era, startups aren't winning by hiring faster — they're winning by automating as many internal functions as possible. In this episode of Main Function, Garry breaks down how tiny teams are beating companies 20x their size by building automations into every workflow, from engineering to ops to customer support.

    14 February 2026, 8:06 pm
  • 22 minutes 35 seconds
    OpenClaw And The Future Of Personal AI Agents

    You’ve probably already heard all about OpenClaw (formerly Clawdbot/Moltbot). The viral sensation is an open-source AI assistant that runs on your own device, connects with messaging apps you already use, and goes beyond chat to actually execute tasks like managing your email, calendars, files, workflows, and more. Now meet the man behind it. YC’s Raphael Schaad sat down with Peter Steinberger, the creator of OpenClaw, to discuss the “aha” moment behind the viral personal AI agent, why local-first agents could replace many of today’s apps, and how personal agents will reshape the future of software.

    Chapters:

    00:00 – OpenClaw takes over the internet

    00:44 – Life after going viral

    01:28 – Why OpenClaw took off, what sets it apart

    02:56 – Bots talking to bots (and hiring humans)

    04:11 – From “God AI” to swarm intelligence

    05:07 – Peter’s original “aha” moment

    06:38 – Rebuilding the agent as a conversation

    07:38 – The moment it exceeded expectations

    10:21 – Are apps going to disappear?

    12:31 – Memory, data silos, and ownership

    14:39 – The privacy reality of personal agents

    15:05 – Letting the bot loose in public Discord

    16:55 – Giving an agent a personality

    18:19 – Contrarian building philosophy

    20:09 – CLIs vs MCPs

    21:28 – Building for humans first

    21:46 – The road ahead

    Apply to Y Combinator: https://www.ycombinator.com/apply

    Work at a startup: https://www.ycombinator.com/jobs


    7 February 2026, 4:00 pm
  • 45 minutes 59 seconds
    We're All Addicted To Claude Code

    Wondering why your maker-turned-manager suddenly seems distracted in meetings? Maybe they're addicted to coding agents! In this episode of Lightcone, Calvin French-Owen — a co-founder of Segment and former engineer on OpenAI's Codex team — joins us to talk about why coding agents suddenly feel so powerful, the differences between Codex, Claude Code, and Cursor, and what the future of work will look like.

    6 February 2026, 3:00 pm
  • 5 minutes 41 seconds
    How To Get Your First Customers

    When you're starting out, it isn’t enough to just build a minimum viable product. You also need a minimum evolvable product - one that can adapt to the needs of those critical early customers. In this episode of Main Function, YC General Partner Ankit Gupta offers an update to the classic MVP playbook. He’ll outline strategies for getting your first customers, the power of adaptability and how feedback from early users will ultimately shape the future of your product and your company.

    Apply to Y Combinator: https://www.ycombinator.com/apply

    Work at a startup: https://www.ycombinator.com/jobs

    Chapters:

    00:00 – The Minimum Evolvable Product

    00:46 – Finding the First Believers

    01:29 – Counterintuitive Rules To Get Early Users

    02:10 – Learn Fast, Don’t Fear Churn

    02:52 – How Early Users Shape the Market You Enter

    04:22 – Tesla Case Study

    05:14 – How To Build To Evolve

    14 January 2026, 4:00 pm
  • 15 minutes 43 seconds
    Inside The Startup Building Reusable Rockets

    Stoke Space is racing to build the world's first fully reusable rockets that can launch, survive reentry, and fly again and again. In this episode of Hard Tech, YC’s Aaron Epstein sits down with Stoke Space co-founders Andy Lapsa and Tom Feldman to find out why they chose to take on one of the hardest problems in rocket science, how an obsession with efficiency gives them an edge, and what full reusability could unlock for the future of spaceflight.

    Apply to Y Combinator: https://www.ycombinator.com/apply

    Work at a startup: https://www.ycombinator.com/jobs



    8 January 2026, 5:00 pm
  • 30 minutes 22 seconds
    What Surprised Us Most In 2025

    2025 was the year AI stopped feeling chaotic and started feeling buildable. In this Lightcone episode, the YC partners break down the surprises of the year, from shifting model dominance to why the real opportunity is moving back to the application layer, and why the next wave of AI startups may be just getting started.

    22 December 2025, 3:52 pm
  • More Episodes? Get the App